ACMT Toxicology Visual Pearls: Getting Caught Yellow-handed

Which bodybuilding supplement is associated with hyperthermia and this clinical image? 2,4-dinitrophenol (DNP) Beta-carotene Caffeine Creatine Dimethyl amylamine (DMAA) This post was peer reviewed on behalf of ACMT by Bryan Judge, Louise Kao, and David Wood. References Holborow A, Purnell RM, and Wong JF. Beware the yellow slimming pill: fatal 2,4-dinitrophenol poisoning. BMJ Case Report, April 4, 2016. PMID: 27045052 Lu Y, Jiang J, and Huang W. Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning. Biomed & Biotech, vol. 12, no. 3, pp. 189-192, Mar 2011 PMID: 21370503 Grundlingh J, Dargan P, El-Zanfaly M, and Wood D. .2,4-Dinitrophenol (DNP): A weight loss agent with significant acute toxicity and risk of death. Journal of Medical Toxicoogy, vol. 7, pp. 205-212, 2011. PMID: 21739343 Personne M, Ekstrom M, and Iveroth M. 2,4-dinitrophenol – a lethal dieting agent. Lakartidningen, vol. 111, no. 22-23, pp. 996-997, 2014 May 27-Jun 10. PMID: 24946482 Tewari A, Ali A, O’Donnel A, and Butt M. Weight loss and 2,4-dinitrophenol poisoning. Br. J. Anesth., vol. 102, no. 4, pp. 556-7, Apr. 2009. PMID: 19286775 Toxicologic Profile for Dinitrophenols. US Department of Health and Human Services, Agency for Toxic Substance and Disease Registry, May 2019, available at: https://www.atsdr.cdc.gov/ToxProfiles/tp64.pdf Kopec KT, Kim T, Mowry J, Aks S, Kao L. Role of dantrolene in dinitrophenol (DNP) overdose: A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. doi: 10.1016/j.ajem.2019.03.035. Epub 2019 Mar 23. PMID: 30948257 Kumar S, Barker K, and Seger D. Dinitrophenol-Induced Hyperthermia Resolved with Dantrolene Administration. Clinical Toxicology, vol. 40, no. 5, p. 689, 2002. Smits G. Successful Treatment of a Dinitrophenol Overdose. Clinical Toxicology, vol. 48, no. 3, pp. 255-256, 2010. P. Halsall and F. Ellis, “The Control of Muscle Contracture by the … Continue reading ACMT Toxicology Visual Pearls: Getting Caught Yellow-handed