Transient Synovitis vs Septic Arthritis of the Hip

Transient Synovitis vs Septic Arthritis of the Hip

2016-11-11T18:38:43+00:00

Limping is a common reason for parents to bring their children to emergency departments. It is known that 77% of acute, atraumatic limp is dealt with in the ED, and 20% do not even complain of pain.1 Our job as physicians is to complete appropriate assessments to not miss any serious pathology. Specifically, differentiating between transient synovitis (TS) and septic arthritis (SA) of the hip can be difficult and frustrating for everyone. What is your approach?

TS is an inflammation of the joint space, classically following a URI, with a benign clinical course. SA is an infectious arthritis associated with poor outcomes with diagnostic delays, including osteonecrosis, growth arrest, and sepsis. Both can both present as an atraumatic, acutely irritable hip with progressive signs of fever, limp, refusal to bear weight, limited range of motion, and abnormal labs. This overlap makes them difficult to differentiate. Although the diagnostic gold standard is to perform an invasive arthrocentesis (positive synovial culture), can we diagnose using clinical criteria alone, such as Kocher’s criteria?

Kocher’s clinical criteria for septic arthritis

  1. Fever > 38.5C
  2. Non-weight bearing on affected side
  3. ESR > 40 mm/hr
  4. WBC >12k

Can clinical criteria distinguish TS from SA?2–6

Conclusions about using Kocher’s Criteria

Kocher’s clinical criteria is, at best, only OK at helping to differentiate TS from SA.

It is, however, the most studied criteria that we have. Despite that, there is still inadequate external validation studies (Caird et al study: 0 predictors still has 16.9% chance of SA4). The criteria are helpful depending on pretest assumptions. So when applied to a HIGH risk group with HIGH prevalence of SA, the predictive value of the algorithm is high.And when applied to a LOW risk group with a LOW prevalence of SA, the predictive value of the algorithm is low.

What does the American College of Radiology (ACR) recommend as the initial imaging modality?

  • If traumatic mechanism: XR should be primary imaging modality
  • If no trauma and no signs of infection: XR should be primary imaging modality, and if negative consider US Hip
  • If no trauma, possible signs of infection: US should be primary imaging modality, and if negative consider XR; If both are negative and still concerned for SA, MRI is the next imaging modality of choice

What is the Role of US in Differentiating TS from SA?7

  • What they did:
    • 154 Children (91 boys and 63 girls)
    • Mean age 4.3 years
    • Hip pain suspected to be TS vs SA based on clinical and lab findings sent for US
  • Primary Outcome:
    • Accuracy of US of hip to diagnose SA of hip and differentiate from TS
  • Results:
    • Use of clinical parameters, lab, and XR: Sens 74%, spec 74%, PPV 76%
    • Hip US alone: Sens 86.4%, spec 89.7%, PPV 87.9%
    • 8/69 (11.6%) of hip US’s that were negative for SA were ultimately confirmed to have SA
  • Conclusions:
    • Clinical parameters and XR are only suggestive in diagnosing hip SA. Hip US performs only slightly better diagnostically. Both, however, are UNRELIABLE in definitively differentiating SA from TS.
    • Hip US can confirm and exclude hip effusion, but can have false negatives, especially early in disease process (<24hours)

BOTTOM LINE

Given that the Kocher clinical criteria and imaging (XR and US) modalities are only moderately helpful, at best, you should use a combination of your history and physical findings, imaging results, and gestalt to help guide your management decisions. Many clinicians err conservatively and perform an arthrocentesis in uncertain cases despite it being a relatively invasive procedure.

What diagnostic approach do you use?

1.
Fischer S, Beattie T. The limping child: epidemiology, assessment and outcome. J Bone Joint Surg Br. 1999;81(6):1029-1034. [PubMed]
2.
Kocher M, Zurakowski D, Kasser J. Differentiating between septic arthritis and transient synovitis of the hip in children: an evidence-based clinical prediction algorithm. J Bone Joint Surg Am. 1999;81(12):1662-1670. [PubMed]
3.
Jung S, Rowe S, Moon E, Song E, Yoon T, Seo H. Significance of laboratory and radiologic findings for differentiating between septic arthritis and transient synovitis of the hip. J Pediatr Orthop. 2003;23(3):368-372. [PubMed]
4.
Caird M, Flynn J, Leung Y, Millman J, D’Italia J, Dormans J. Factors distinguishing septic arthritis from transient synovitis of the hip in children. A prospective study. J Bone Joint Surg Am. 2006;88(6):1251-1257. [PubMed]
5.
Luhmann S, Jones A, Schootman M, Gordon J, Schoenecker P, Luhmann J. Differentiation between septic arthritis and transient synovitis of the hip in children with clinical prediction algorithms. J Bone Joint Surg Am. 2004;86-A(5):956-962. [PubMed]
6.
Kocher M, Mandiga R, Zurakowski D, Barnewolt C, Kasser J. Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children. J Bone Joint Surg Am. 2004;86-A(8):1629-1635. [PubMed]
7.
Zamzam M. The role of ultrasound in differentiating septic arthritis from transient synovitis of the hip in children. J Pediatr Orthop B. 2006;15(6):418-422. [PubMed]

Salim Rezaie, MD

Salim Rezaie, MD

ALiEM Associate Editor
Clinical Assistant Professor of EM and IM
University of Texas Health Science Center at San Antonio
Founder, Editor, Author of R.E.B.E.L. EM and REBEL Reviews
  • I sort of modify Kocher’s original criteria and add a CRP.
    If all of those are normal (T, ESR, CRP, WBC, walking), I usually stop there.
    If 1 or more abnormal, I xray (with comparison). If that’s normal, sometimes I stop there, unless they have markedly abnormal lab value.
    If the xray is not normal, then I US. If the US is abnormal, I consult ortho.

  • I agree with Justin’s work-up. I don’t know about others, but is nearly impossible to get an ultrasound on a kid in my hospital, much less US of the hip. One of the reasons I continue to brush up my own US skills.

  • Some of the studies above use CRP as well, and I can see that as a variant of the Kocher criteria. Our orthopedists are CRP fans in general, and so I tend to get for inflammatory/infectious workups (spinal epidural abscess, septic arthritis, etc). I use a similar approach as Justin.

  • Thank you for all the comments on the post. In residency I was taught the Kocher criteria followed by US for SA vs TS, but never really looked at the literature. Had a recent case of painful pediatric hip in my ED, so thought I would look up the literature. I was shocked how not specific Kocher’s criteria and US were. That being said, I follow a very similar approach to Justin, but have the same problem as Matt…..it is nearly impossible to get a hip US in our ED.

    Salim

    • At my children’s hospital, I can get the US fairly easily. However, I don’t have my own US to use in the department.
      At the adult hospital, all bets are off. It’s actually easier to transfer the patient with “suspicion of septic joint” than it is to get it performed, then read.