MicromedexWe often have less than optimal IV access to administer fluids, blood products, and medications in sick ED patients. If more than one medication needs to be infused in the same line, how do we know if they are compatible? The gold standard for checking IV compatibility is Trissel’s Stability of Compounded Formulations. 1 But a textbook doesn’t help us in critical situations. Is there a better way?


Use the free Micromedex IV Compatibility app

Many institutions and schools subscribe to Micromedex products, which translates into free access for you.

Step 1

Download the free Micromedex IV Compatibility app from iTunes or Google Play. Micromedex also has free drug information and drug interaction apps.

Step 2

Navigate to the Micromedex page from your hospital or school library.

Step 3

Click on ‘Download Mobile Apps.’

Micromedex home page

Step 4

Scroll down to the information for the IV Compatibility app. The password will be available for you to enter into the app. This password changes every 3 months (usually you realize it when you’re in the middle of a resuscitation), so make sure to check back and update it periodically.

Compatability app 4

Step 5

Enter in the medications you’d like to check for compatibility.

Bicarb-epi 5

Step 6

You can check compatibility for y-site (i.e. running through the same IV line) or medications mixed in the same syringe.

syringe 7

Step 7

References and more detailed information are provided if you’d like to look into it further.

References 8

Timely compatibility information is very helpful for nurses, pharmacists, prehospital providers, and physicians. The free app from Micromedex lets you have access to this information at your fingertips.

Disclaimer: We have no affiliation with Truven Health Analytics or Micromedex.

Smith W, Karpinski J, Timpe E, Hatton R. Evaluation of seven i.v. drug compatibility references by using requests from a drug information center. Am J Health Syst Pharm. 2009;66(15):1369-1375. [PubMed]
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP

Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP

Leadership Team, ALiEM
Creator and Lead Editor, Capsules and EM Pharm Pearls Series
Attending Pharmacist, EM and Toxicology, MGH
Associate Professor of EM, Division of Medical Toxicology, Harvard Medical School
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP


EM Pharmacist & Toxicologist @MassGeneralEM | Asst Prof @HarvardMed/@EMRES_MGHBWH | @ALiEMteam leadership | Capsules creator, ALiEMU | President, ABAT | #FOAMed
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP

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