Which of the following rodenticides, often used to kill the rodent pictured, causes seizure-like activity without altered mental status or a postictal period?
- Barium
- Brodifacoum
- Carbamate
- Strychnine
- Zinc phosphide
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This post has been peer-reviewed on behalf of ACMT by Dr Bryan Judge, Dr Louise Kao, and Dr David Wood.
References
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- Mackerer CR, Kochman RL, Shen TF, Hershenson FM. The binding of strychnine and strychnine analogs to synaptic membranes of rat brainstem and spinal cord. J Pharmacol Exp Ther. 1977;201(2):326-331. PMID: 16120
- Curtis DR, Duggan AW, Johnston GA. The specificity of strychnine as a glycine antagonist in the mammalian spinal cord. Exp Brain Res. 1971;12(5):547-565. doi:10.1007/BF00234248. PMID: 5093729
- Teitelbaum DT, Ott JE. Acute strychnine intoxication. Clin Toxicol. 1970;3(2):267-273. doi:10.3109/15563657008990475. PMID: 5527848
- Chan Y. Strychnine. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank’s Toxicological Emergencies, 11e New York, NY: McGraw-Hill; 2019
- Boyd RE, Brennan PT, Deng JF, Rochester DF, Spyker DA. Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. Am J Med. 1983;74(3):507-512. doi:10.1016/0002-9343(83)90999-3. PMID: 6829597
- Hardin JA, Griggs RC. Diazepam treatment in a case of strychnine poisoning. Lancet. 1971;2(7720):372-373. doi:10.1016/s0140-6736(71)90085-7. PMID: 4105067
- Jackson G, Ng SH, Diggle GE, Bourke IG. Strychnine poisoning treated successfully with diazepam. Br Med J. 1971;3(5773):519-520. doi:10.1136/bmj.3.5773.519. PMID: 341168
- Maron BJ, Krupp JR, Tune B. Strychnine poisoning successfully treated with diazepam. J Pediatr. 1971;78(4):697-699. doi:10.1016/s0022-3476(71)80480-8. PMID: 5547830