Which bodybuilding supplement is associated with hyperthermia and this clinical image?
- 2,4-dinitrophenol (DNP)
- Dimethyl amylamine (DMAA)
This post was peer reviewed on behalf of ACMT by Bryan Judge, Louise Kao, and David Wood.
- Holborow A, Purnell RM, and Wong JF. Beware the yellow slimming pill: fatal 2,4-dinitrophenol poisoning. BMJ Case Report, April 4, 2016. PMID: 27045052
- Lu Y, Jiang J, and Huang W. Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning. Biomed & Biotech, vol. 12, no. 3, pp. 189-192, Mar 2011 PMID: 21370503
- Grundlingh J, Dargan P, El-Zanfaly M, and Wood D. .2,4-Dinitrophenol (DNP): A weight loss agent with significant acute toxicity and risk of death. Journal of Medical Toxicoogy, vol. 7, pp. 205-212, 2011. PMID: 21739343
- Personne M, Ekstrom M, and Iveroth M. 2,4-dinitrophenol – a lethal dieting agent. Lakartidningen, vol. 111, no. 22-23, pp. 996-997, 2014 May 27-Jun 10. PMID: 24946482
- Tewari A, Ali A, O’Donnel A, and Butt M. Weight loss and 2,4-dinitrophenol poisoning. Br. J. Anesth., vol. 102, no. 4, pp. 556-7, Apr. 2009. PMID: 19286775
- Toxicologic Profile for Dinitrophenols. US Department of Health and Human Services, Agency for Toxic Substance and Disease Registry, May 2019, available at: https://www.atsdr.cdc.gov/ToxProfiles/tp64.pdf
- Kopec KT, Kim T, Mowry J, Aks S, Kao L. Role of dantrolene in dinitrophenol (DNP) overdose: A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. doi: 10.1016/j.ajem.2019.03.035. Epub 2019 Mar 23. PMID: 30948257
- Kumar S, Barker K, and Seger D. Dinitrophenol-Induced Hyperthermia Resolved with Dantrolene Administration. Clinical Toxicology, vol. 40, no. 5, p. 689, 2002.
- Smits G. Successful Treatment of a Dinitrophenol Overdose. Clinical Toxicology, vol. 48, no. 3, pp. 255-256, 2010.
- P. Halsall and F. Ellis, “The Control of Muscle Contracture by the Action of Dantrolene on the Sarcolemma,” Acta Anaesthesiol Scand., vol. 27, pp. 229-232, 1983.