MIA 2012: Campagna JD, et al. The use of cephalosporins in penicillin-allergic patients: a literature review. J Emerg Med. 2012 May;42(5):612-20

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  • For patients with penicillin (PCN) allergies, it is safe to administer third- and fourth-generation cephalosporins (CPN) with no fear of cross reaction.
  • Use of first- and second-generation CPN should only be avoided when the penicillin antibiotic shares structurally similar R1 side chains.

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By |2016-11-11T18:42:23-08:00Jan 1, 2013|Tox & Medications|

MIA 2012: Nishijima DK et al. Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use. Ann Emerg Med. 2012 Jun;59(6):460-8.e1-7.

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CREST study: Patients presenting to the emergency room with blunt head trauma and preinjury warfarin or clopidogrel use have a high incidence of immediate intracranial hemorrhage, but a very low incidence delayed intracranial hemorrhage. Thus, if the initial head CT is negative, you should be able to discharge the patient home…

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By |2016-11-11T18:42:23-08:00Jan 1, 2013|Tox & Medications, Trauma|

MIA 2012: Backes D, et al. Time-dependent test characteristics of head computed tomography in patients suspected of nontraumatic subarachnoid hemorrhage. Stroke. 2012 Aug;43(8):2115-9

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  • 100% sensitive and specific if < 6 hours from headache onset
  •  90% sensitive if after 6 hours

A noncontrast head CT can effectively rule out atraumatic subarachnoid hemorrhage (aSAH) in patients who present with acute headache within six hours after ictus. Those who present outside this time window or present atypically for SAH (ie neck pain) require further workup, including a lumbar puncture.

By |2016-11-11T18:42:23-08:00Jan 1, 2013|Neurology, Radiology|
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