SAEM Clinical Images Series: Unusual Presentation of an Exophytic Tumor

A 60-year-old African American female without a past medical history presented to the emergency department with a complaint of a “hard, yellowish brown, growth” on her right upper abdomen. The patient reported that it had been present and slowly enlarging over a two-year period and was now causing pain when it “snags on clothing”.
Skin: 9.5 cm, firm, curved, exophytic, keratotic, tumor protruding from the right upper abdominal wall.
Non-contributory
Histopathology confirmed a diagnosis of a benign Cutaneous Horn a.k.a. Cornu Cutaneum (latin). Cutaneous horns are yellow or white exophytic hyperkeratotic projections formed in reaction to a number of physical and disease processes. Defined by having a height more than one-half the size of their base in diameter, they are slow-growing and found in conical, cylindrical, pointed, or curved configurations. Their exact pathogenesis is unknown, they occur equally among genders, are more common in the elderly and fair-skinned individuals, and are predominant in sun-exposed areas of the body.
Cutaneous horns are formed in reaction to a number of underlying conditions and are most commonly (>60%) benign, however underlying premalignant and malignant diseases may exist. Histopathologic evaluation of the skin at the base of the lesion is necessary to establish any associated disease. Benign cutaneous horns may form from chronic irritation and are affiliated with numerous skin conditions, most commonly seborrheic keratosis. Links to multiple other skin diseases including psoriasis, discoid lupus erythematosus, sarcoidosis, molluscum contagiosum, and Bowen’s disease exist. Actinic keratosis is the most common premalignant etiology. Cutaneous horns reflecting a malignancy are predominantly associated with wider and erythematous bases in sun-exposed areas of the body in elderly males. Cutaneous horns arising from malignancy tend to occur from squamous cell carcinoma although associations with at least nine other malignancies including basal cell carcinoma, malignant melanoma, Paget’s disease of the breast, Kaposi’s sarcoma, and renal cell carcinoma exist.
Take-Home Points
Cutaneous horns occur most frequently with aging in fair-skinned individuals on areas exposed to ultraviolet radiation.
Cutaneous horns are hyperkeratotic epithelial lesions formed in reaction to multiple conditions.
Complete excisional biopsy including full thickness skin from the base is the treatment of choice and is required for histopathologic analysis.
Cutaneous horns, although most commonly benign, may reflect a premalignant or malignant disease process requiring further evaluation and surveillance.
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Thiers BH, Strat N, Snyder AN, Zito PM. Cutaneous Horn. 2023 Mar 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 33085427.
Vanik S, Mehta S, Shah R, Trivedi P, Rathod P, Bhatt S. Giant Cutaneous Horn: Is It a Tip of An Iceberg? Two Case Reports and a Review of Literature. Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):5432-5435. doi: 10.1007/s12070-021-02719-1. Epub 2021 Jul 6. PMID: 36742859; PMCID: PMC9895721.
Copcu E, Sivrioglu N, Culhaci N. Cutaneous horns: are these lesions as innocent as they seem to be? World J Surg Oncol. 2004 Jun 3;2:18. doi: 10.1186/1477-7819-2-18. PMID: 15176977; PMCID: PMC421749.
Copyright
Images and cases from the Society of Academic Emergency Medicine (SAEM) Clinical Images Exhibit at the 2023 SAEM Annual Meeting | Copyrighted by SAEM 2023 – all rights reserved. View other cases from this Clinical Image Series on ALiEM.















