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Bleeding in general is bad. Bleeding while on anticoagulants is VERY bad. Dr. Rahul Patwari reviews the pathophysiology of coagulation, the various reversal agents, and treatment approaches we can use. In this five-part series where all videos are less than 10 minutes, Rahul goes from the basic physiology of coagulation all the way to the complex reasoning and approaches to reversing anticoagulants. These are worth a quick look and review.

Physiology of coagulation

The coagulation cascade

Reversing coumadin, part 1

Reversing coumadin, part 2

– use of prothrombin complex concentrates (PCC)

Reversing other anticoagulant drugs

  • low molecular weight heparin
  • dabigatran
  • rivaroxaban
  • thrombolytics
  • aspirin
  • clopidogrel
  • abciximab
Michelle Lin, MD
ALiEM Founder and CEO
Professor and Digital Innovation Lab Director
Department of Emergency Medicine
University of California, San Francisco
Michelle Lin, MD


Professor of Emerg Med at UCSF-Zuckerberg SF General. ALiEM Founder @aliemteam #PostitPearls at Bio:
Michelle Lin, MD