Paucis Verbis: Overanticoagulation and supratherapeutic INR

I find it amazing that I know more non-emergency physicians virtually in the social media world rather than in person. Primarily through Twitter, I follow and am followed by medical educators from various specialties. If you haven’t joined Twitter yet, I think it might be time. There is a whole world of collaboration and conversation going on in this virtual community, which crosses specialties and geography.

Last week, Dr. Javier Benítez (@jvrbntz) was tweeting a Question of the Day, referencing a 2010 Paucis Verbis card on overanticoagulation, which was based on the 2008 American College of Chest Physicians (ACCP) guidelines. About 8 minutes after I retweeted his question, Dr. Roy Arnold (@cholerajoe), a pulmonary/critical care physician kindly informed me that the 2012 ACCP guidelines have been out since February.

So this PV card is replacing the 2010 card with revised recommendations. For more in-depth discussion, definitely take a look at Dr. Scott Weingart’s great podcast over at EMCrit. He helps to clarify holes which the 2012 ACCP guidelines don’t really address such as:

What if the patient is minorly bleeding with a high INR?

Oral vitamin K and 15 mL/kg FFP

What if you only have the 3-factor PCC (factors II, IX, X) and not the recommended 4-factor PCC (factors II, IX, X plus factor VII)?

If PCC is indicated, add recombinant factor VIIa or FFP to the 3-factor PCC to cover for factor VII.

PV Card: Overanticoagulation and Supratherapeutic INR

Adapted from [1]
Go to ALiEM (PV) Cards for more resources.

Reference

Holbrook A, Schulman S, Witt D, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e152S-84S. [PubMed]

By Michelle Lin, MD|2021-10-10T08:47:06-07:00Aug 10, 2012|ALiEM Cards, Heme-Oncology, Tox & Medications|

Mythbuster: The 10% cephalosporin-penicillin cross-reactivity risk

To give or not to give a cephalosporin in penicillin-allergic patients?

I remember back to my days in pharmacy school when I learned that there was approximately a 10% risk of cross-reactivity, if a cephalosporin was given to a penicillin-allergic patient. They probably said something about the risk being less with 3rd and 4th generations cephalosporins, but lets be honest… who remembers anything but that magic 10%? When I started working more with physicians, I found that they also learned the same 10% rule in medical school. Well, I guess that means it’s fact, right? Not so fast!

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By Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP|2018-05-28T22:12:57-07:00Aug 9, 2012|Tox & Medications|

Trick of the Trade: Massaging a mandibular dislocation back in

Continuing the theme of mandibular dislocation tricks (protecting your thumbs, post-reduction stabilization), Dr. Daniel Gromis from Advocate Christ Medical Center describes a novel reduction technique, based on the Cunningham shoulder reduction technique using muscle relaxation.

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By Michelle Lin, MD|2019-01-28T22:17:16-08:00Jul 31, 2012|ENT, Tricks of the Trade|

D-Dimer: To order or not to order?

That’s the question when it comes to risk stratifying a patient for a pulmonary embolism with a low pretest probability. One should consider confounding conditions which may cause an elevated D-Dimer level. There’s always confusion about what may cause an elevated D-Dimer besides venous thromboemboli. So I thought I would make a pocket card as a reminder.

PV Card: D-Dimer Test

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Adapted from [1]
Go to ALiEM (PV) Cards for more resources.

Reference

Wakai A, Gleeson A, Winter D. Role of fibrin D-dimer testing in emergency medicine. Emerg Med J. 2003;20(4):319-325. [PubMed]

By Michelle Lin, MD|2021-10-10T08:49:42-07:00Jul 27, 2012|ALiEM Cards, Cardiovascular, Pulmonary|

Trick of the Trade: Photograph slit lamp findings

How do you capture the image of the eye on slit lamp exam either for the patient or your ophthalmology consult? It’s often easier to show someone a photo rather than trying to describe that atypical dendritic lesion, degree of corneal edema, or pattern of corneal abrasion.

You, however, don’t have the expensive camera attachment (nor a SLR camera for that matter).

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By Michelle Lin, MD|2019-01-28T22:18:01-08:00Jul 24, 2012|Ophthalmology, Tricks of the Trade|

Medication error is something that we all fear in Emergency Medicine and do our best to avoid. Here’s a scenario and simple approach for you, provided by Zlatan Coralic, PharmD (Assistant Clinical Professor in the UCSF School of Pharmacy).

You are an emergency physician working in an underserved country. You are presented with an asthmatic kid with severe retractions and tight wheezes. Multiple nebulizers and corticosteroids have failed. You want to try some magnesium sulfate before risking intubation in a place with no reliable access to ventilator equipment. You know the dose should be 1 gm IV over 20 minutes.

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By Zlatan Coralic, PharmD|2016-11-11T18:44:27-08:00Jul 17, 2012|Tox & Medications, Tricks of the Trade|

Paucis Verbis: Blunt cardiac injury

Do you always get a troponin for patients who sustain blunt chest trauma?

Hopefully your answer is no. Of note, it is also NOT indicated as a screening test for those in whom you suspect a blunt cardiac injury (BCI). It can be normal in the setting of arrhythmias and it can be falsely elevated in the setting of catecholamine release or reperfusion injury from hypovolemic shock.

The initial screening test should include an ECG and a FAST ultrasound exam. If you have abnormal ECG findings, then a troponin is warranted (in addition to hospital admission).

Below summarizes a suggested algorithm from the recent EM Clinics of North America publication series. Definitive statements are challenging because there is no gold standard to diagnose BCI.