ACMT Toxicology Visual Pearl: A Bane to Existence

What is the primary cause of death following ingestion of the plant pictured?
- Acute liver failure
- Arrhythmia
- Disseminated intravascular coagulation
- Status epilepticus

What is the primary cause of death following ingestion of the plant pictured?

A 53-year-old woman with no significant past medical history presented to the emergency department with a 3-day history of double vision on leftward gaze. She initially presented to urgent care with a chief complaint of chest heaviness and concern that her blood pressure was too high, but was sent to the emergency department for further cardiac and neurological evaluation after her urgent care provider noticed abnormal eye movement. She endorsed mild, intermittent headaches associated with diplopia when looking to the left. However, she denied any blurry vision when looking forward. She denied any trauma or falls.

A 30-year-old female with a past medical history of Crohn’s Disease presented to the ED for evaluation of an acutely bruised right 4th finger. She stated she was typing on a computer keyboard approximately 10 minutes prior to presentation and she noticed a sudden popping sensation at the base of her right ring finger. After the popping sensation, she noticed a cool sensation of the finger and numbness to the entire finger. Shortly after that, the finger turned purple, so she came to the Emergency Department for evaluation. She denied pain in the hand and has had no problems moving the finger. She denied trauma to the hand or finger. No other complaints or issues. She noted that she has had this once in the past, which self-resolved on its own in 10 days a few months ago in the same situation.

A 28-year-old male presented to the ED for evaluation of an injury to his right eye. While working out with an exercise band, it snapped back, hitting the patient in the right eye. He experienced blurry vision and excess eye tearing immediately after the incident occurred. The patient also developed gross blood over the front of the eye.

In July 2022, a 32-year-old male with a past medical history of HIV (on antiretroviral therapy, CD4 390, viral load undetectable) presented to the emergency department with constitutional symptoms and a rash for 4-5 days. His symptoms included malaise, body aches, subjective fevers, a sore throat, tender, swollen neck glands, body rash, and irritation of his left eye. He also noticed fluid-filled vesicles on his face, neck, trunk, and extremities. He denied travel outside the U.S. but reported a recent trip to New Orleans. He denied any new sexual partners or known exposure to individuals with similar symptoms.

Read this tutorial on the use of point of care ultrasonography (POCUS) for pediatric renal and bladder ultrasonography. Then test your skills on the ALiEMU course page to receive your PEM POCUS badge worth 2 hours of ALiEMU course credit.
Serena is a 9-year-old girl who comes into the emergency department complaining of one day of left flank and left lower quadrant pain (LLQ). The pain is intermittent, sharp, severe, and associated with 2 episodes of nonbloody, nonbilious emesis. Her mother denies any fevers, upper respiratory symptoms, sore throat, or diarrhea. She adds that her daughter has complained of 2-3 episodes of dysuria and gross hematuria over the last few days.
On arrival, her vital signs are:
| Vital Sign | Finding |
|---|---|
| Temperature | 99 F |
| Heart Rate | 115 bpm |
| Blood Pressure | 97/50 |
| Respiratory Rate | 19 |
| Oxygen Saturation (room air) | 100% |
You find her lying on the gurney, uncomfortable appearing, and intermittently crying. She has a normal HEENT, neck, cardiac, respiratory, and back examination. She has no flank tenderness, but she does cry out with palpation of the LLQ and suprapubic areas.
Given her pain with a history of intermittent hematuria and dysuria, you perform a renal and bladder point of care ultrasound (POCUS) examination.
Using the curvilinear probe, you perform a POCUS on the bladder and both kidneys (Video 12).
Labs showed a slight leukocytosis with a serum WBC of 13 x109/L but no left shift and a normal creatinine. Urinalysis was positive for blood, RBC’s, and crystals but negative for glucose, ketones, leukocyte esterase, nitrites, WBC’s, squamous cells, and bacteria. The pain and vomiting were well-controlled with ketorolac and ondansetron, respectively. Urology was consulted and recommended medical management. The patient was discharged on tamsulosin and given urine-straining instructions.
At her pediatrician clinic visit 2 weeks later, the patient had passed the stone and was asymptomatic.

Which medication can be derived from the bark of the pictured tree?